Unlocking the Anti-Aging Potential of Protein in Human Cells – Neuroscience News

Summary: Researchers have uncovered an anti-aging function in a protein, ATSF-1, found deep within human cells. This protein controls a delicate balance between the creation and repair of mitochondria, which produce energy and contribute to cell aging.

By enhancing ATSF-1 function, cellular health was improved in a study using C. elegans worms. This discovery could have major implications for healthy aging and mitochondrial diseases.

Key Facts:

Source: University of Queensland

Researchers at The University of Queensland have found an anti-aging function in a protein deep within human cells. 

Associate Professor Steven Zuryn and Dr Michael Dai at the Queensland Brain Institute have discovered that a protein called ATSF-1 controls a fine balance between the creation of new mitochondria and the repair of damaged mitochondria.

Mitochondria, with their own DNA, produce energy within cells to power biological functions but the toxic by-products of this process contribute to the rate at which the cell ages.

“In conditions of stress, when mitochondrial DNA has been damaged, the ATSF-1 protein prioritises repair which promotes cellular health and longevity,” Dr Zuryn said.

As an analogy, Dr Zuryn likened the relationship to a race car needing a pitstop.

“ATSF-1 makes the call that a pitstop is needed for the cell when mitochondria need repairs,” he said.

“We studied ATFS-1 in C. elegans, or round worms and saw that enhancing its function promoted cellular health, meaning the worms became more agile for longer.

“They didn’t live longer, but they were healthier as they aged.”

“Mitochondrial dysfunction lies at the core of many human diseases, including common age-related diseases such as dementias and Parkinson’s.

“Our finding could have exciting implications for healthy aging and for people with inherited mitochondrial diseases.”

Understanding how cells promote repair is an important step towards identifying possible interventions to prevent mitochondrial damage.

“Our goal is to prolong the tissue and organ functions that typically decline during aging by understanding how deteriorating mitochondria contribute to this process,” Dr Dai said.

“We may ultimately design interventions that keep mitochondrial DNA healthier for longer, improving our quality of life,” Dr Dai said.

About this aging and genetics research news

Author: Lisa Clarke
Source: University of Queensland
Contact: Lisa Clarke – University of Queensland
Image: The image is credited to Neuroscience News

Original Research: Closed access.
ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription” by Steven Zuryn et al. Nature Cell Biology

ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome (mtDNA) requires separate enzymatic activities that can sterically compete1, suggesting a life-long trade-off between these two processes.

Here in Caenorhabditis elegans, we find that the bZIP transcription factor ATFS-1/Atf5 regulates this balance in favour of mtDNA repair by localizing to mitochondria and interfering with the assembly of the mitochondrial pre-initiation transcription complex between HMG-5/TFAM and RPOM-1/mtRNAP.

ATFS-1-mediated transcriptional inhibition decreases age-dependent mtDNA molecular damage through the DNA glycosylase NTH-1/NTH1, as well as the helicase TWNK-1/TWNK, resulting in an enhancement in the functional longevity of cells and protection against decline in animal behaviour caused by targeted and severe mtDNA damage.

Together, our findings reveal that ATFS-1 acts as a molecular focal point for the control of balance between genome expression and maintenance in the mitochondria.

Join our Newsletter
I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )
Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free.
We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.

This content was originally published here.

Can't Get enough Freebie, Subscribe

We will send you the latest digital Marketing technology and methods that should help you grow your business.

Subscribe to Our list

Custom Keto Diet

 

Exipure

 

All day slimming tea

 

ikaria Juice

 

Apple Cider Vinegar Ebook Membership

More Articles