anti aging This study sought to explore the impact of skim milk enriched with bovine colostrum on the expression of biomarkers related to inflammation, antioxidants, oxidative damage, nutrient metabolism, and genomic stability. Our present results demonstrate a significant decrease in the expression of key pro-inflammatory mediators, including CRP, IL-6, and TNF-α, following the consumption of IgCo bovine colostrum milk. This indicates a potential role in immune function regulation and improvement of inflammatory conditions. In summary, adding IgCo bovine colostrum-enriched skim milk to one’s diet may help reduce the expression of different pro-inflammatory markers, including CRP, IL-6, and TNF-α. Untargeted metabolomics analysis findings suggest that bovine colostrum consumption may induce changes in glycerophospholipid metabolism and cysteine and methionine metabolism pathways, ultimately enhancing immune function in older adults. Consequently, our findings propose that bovine colostrum milk holds promise as a nutraceutical food to support healthy and successful aging. The Effects of 12 Weeks Colostrum Milk Supplementation on the Expression Levels of Pro-Inflammatory Mediators and Metabolic Changes among Older Adults: Findings from the Biomarkers and Untargeted Metabolomic Analysis The trend of aging is a worldwide occurrence, observed across all regions, as the proportion of older individuals continues to rise. According to the United Nations, the global population aged 65 and older is anticipated to reach 1.5 billion by the year 2050. This projection signifies a notable increase from 9.3% to 16% in the share of the global population aged 65 years and above. The association between aging and inflammation is robust. As we age, our bodies undergo various changes, including a gradual decline in immune function, leading to persistent low-grade inflammation. Inflammation is a natural response by the body’s immune system to injury, infection, or tissue damage. However, in older adults, this response can become prolonged and excessive, contributing to age-related conditions like cardiovascular disease, cancer, and neurodegenerative diseases. Characterized by heightened production of pro-inflammatory cytokines, reactive oxygen species (ROS), and other immune system molecules, inflammation plays a central role in these age-related diseases. Lifestyle factors such as an unhealthy diet, sedentary behavior, and stress can exacerbate chronic inflammation even further. Consequently, addressing inflammation holds promise as an intervention to enhance immune function, mitigate age-related diseases, and ultimately improve overall health span. Senescence represents a natural biological process marked by a series of physiological deteriorations. This study aimed to explore the impact of supplementing with bovine colostrum milk on metabolic changes and the expression of various biomarkers related to inflammation, antioxidants, oxidative damage, nutrient metabolism, and genomic stability in older adults. Participants aged 50–69 in a 12-week randomized, double-blinded, placebo-controlled trial were instructed to consume IgCo bovine colostrum-enriched skim milk or regular skim milk (placebo) twice daily. After 12 weeks, the intervention group exhibited lower expression levels of pro-inflammatory mediators (CRP, IL-6, and TNF-α). Nutrients 2023, Published: 18 July 2023 (This article belongs to the Special Issue Nutrition Interventions for Healthy Aging) Colostrum Consumption Provides the Foundation for Life-long Immunity The Crucial Link: Colostrum Shortage and Breastfeeding Challenges Impacting Newborn Immunity and Subsequent GI Health in Later Life Infants fed breast milk have a reduced incidence of gastrointestinal (GI) tract infections than those fed formula or cow’s milk. GI disorders can result in slowed physical growth and neurodevelopment, impaired immunological function, nutrient malabsorption, and early vulnerability to other disorders such as allergies and asthma. Colostrum works as a broad-spectrum anti-bacterial agent that protects newborns from GI infections and contributes to physical development, immune function, and the formation of the GI tract. Colostrum promotes the repair of the GI system and protects adults from gut pathogens (bacteria, viruses, fungus, and yeast) and leaky gut syndrome. Firstly, milk or colostrum contains much more physiologically active peptides, anti-oxidants, anti-inflammatory compounds, and growth-stimulating chemicals than later milk. According to previous evidence, a weakened immune system in newborns causes some GI disorders. Colostrum consumption provides the foundation for life-long immunity. A newborn’s immunity is weakened due to a colostrum shortage or breast-feeding problems. As a result, GI disorders manifest during adolescence or adulthood due to an impaired immune system. Neonatal consumption of colostrum is essential for physical growth, appropriate immune system development, and prevention of GI diseases later in life. brown sugar icebox cookies A prize winning simple cookie recipe with low sugar content of only 11 grams per two cookies. colostrum potentials Bovine colostrum is rich in bioactive molecules like immunoglobulins, growth factors, cytokines, and peptides, known for their anti-inflammatory properties. Its anti-inflammatory effects are attributed to immune response modulation, pro-inflammatory cytokine and enzyme inhibition, and tissue repair promotion. Notably, lactoferrin, a key component, exhibits anti-inflammatory effects by binding to bacterial and viral cell walls, inhibiting pro-inflammatory cytokine production, and modulating immune cells. Bovine colostrum’s growth factors, including IGF-1, TGF-β, and EGF, aid tissue repair and regeneration, crucial in resolving inflammation. Moreover, peptides like lactoperoxidase in bovine colostrum demonstrate anti-inflammatory effects by inhibiting pro-inflammatory cytokine secretion. Dysregulation in glycerophospholipid metabolism, another pathway influenced by bovine colostrum, is linked to chronic inflammation and various diseases. Glycerophospholipids modulate immune cell activity, interact with toll-like receptors, and serve as precursors to inflammatory mediators. Alterations in glycerophospholipid metabolism impact inflammatory responses and correlate with disease development. Furthermore, changes in cysteine and methionine metabolism post-intervention suggest a potential role in inflammation modulation. Methionine, essential for protein synthesis, can contribute to inflammation through homocysteine generation and SAMe regulation. Methionine restriction diets have shown promise in mitigating inflammation associated with aging and obesity. Therefore, reduced pro-inflammatory mediator expression post-consumption of IgCo bovine colostrum milk may be linked to decreased methionine levels. Colostrum milk, often termed “first milk,” is a nutritionally rich and specialized type produced by mammals in the initial days post-birth. Abundant in essential nutrients, including proteins, carbohydrates, vitamins, antibodies, and immune factors, colostrum protects newborns against infections. Beyond its immune-boosting role, colostrum supports gut health and enhances athletic performance. Bovine colostrum, rich in growth factors, aids tissue repair, making it appealing for athletes and injury recovery. Additionally, its antioxidant properties, attributed to enzymes, low molecular antioxidants, proteins, vitamins, and minerals, have been observed. Studies show bovine colostrum’s antioxidative effects in rat intestinal ischemia/reperfusion models and mouse skeletal muscle post-exercise. Given the link between aging, degenerative diseases, and immune decline, we hypothesized that bovine colostrum could boost immunity, alleviate oxidative stress, and support overall health in older adults. Thus, our double-blind, randomized control trial investigated the effects of bovine colostrum-enriched skim milk on biomarkers related to inflammation, antioxidants, oxidative damage, nutrient metabolism, and genomic stability. Metabolomics analysis further explored metabolic changes, enhancing our understanding of the mechanisms behind bovine colostrum’s benefits for older adults. Remember, no more than 6 teaspoons (25 grams) of added sugar per day for women and 9 teaspoons (38 grams) for men. The AHA limits for children vary depending on their age and caloric needs, but range between 3-6 teaspoons (12 – 25 grams) per day. Children under two should have zero grams of sugar per day. If you like natural health tips like the ones above you can learn more in Immune For Life BioBlock®, a nasal spray containing bovine antibodies against SARS-CoV-2. The concept of colostrum-derived nasal spray is led by Professor Mart Ustav. Clinical Trial of BioBlock COVID-19 Nasal Spray Containing Anti-SARS-CoV-2 Antibodies Derived From Bovine Colostrum
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