#252 ‒ Latest insights on Alzheimer’s disease, cancer, exercise, nutrition, and fasting | Rhonda Patrick, Ph.D. – Peter Attia


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Alzheimer’s disease: Rhonda’s evolved thinking on neurodegenerative diseases [2:30]

How Rhonda’s thinking about Alzheimer’s disease has evolved in the past five years 

Generally speaking, are we trying to treat a symptom or are we too far downstream? 

She began to question the underlying causes of dementia 

There are three major types of dementia 

What sort of lifestyle factors and genetic factors do we know really increase the risk of Alzheimer’s disease and dementia?”‒ Rhonda Patrick 

Preventive neurology is still on the outskirts of this field 

If you can prevent type 2 diabetes, does this suggest the possibility of preventing or delaying Alzheimer’s disease? 

Dysfunction in the blood vessels and capillaries that line the blood-brain barrier seem to be a really, really early event that is common between all types of dementia and between type 2 diabetes and APOE-ε4 

The breakdown of the blood-brain barrier in neurodegenerative disease [8:45]

What is the blood-brain barrier (BBB)? 

{end of show notes preview}

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Rhonda Patrick, Ph.D.

Rhonda Patrick earned her BS in biochemistry/ chemistry from the University of California, San diego. She earned her PhD in biomedical science at the University of Tennessee Health Science Center, St. Jude Children’s Research Hospital. In her graduate work she investigated the link between mitochondrial metabolism, apoptosis, and cancer. She discovered a protein critical for cell survival which has two distinct mitochondrial locations with disparate functions. Her work linked the role of this protein in inhibiting apoptosis to a previously unrecognized role in mitochondrial respiration and maintenance of mitochondrial structure. Her dissertation findings were published in the 2012 issue of Nature Cell Biology

Dr. Patrick did her postdoctoral training at Children’s Hospital Oakland Research Institute with Dr. Bruce Ames where she investigated the effects of micronutrient inadequacies on metabolism, inflammation, DNA damaging, and aging. She investigated whether supplementation can reverse such damage. Additionally, she studied the role of vitamin D in brain function, behavior, and other physiological functions. 

Dr. Patrick. also spent time at the Salk Institute for Biological Sciences where she investigated the role of insulin signaling in protein misfolding, a common characteristic of neurodegenerative disease. In 2012, she co-founded FoundMyFitness Science Podcast with the goal of encouraging the public to think about health and longevity using a proactive, preventative approach. [FoundMyFitness]

Rhonda’s podcast: FoundMyFitness 

Rhonda’s website: FoundMyFitness

This content was originally published here.

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